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How Epitalon Works in the Body The effects of aging occur at the cellular level
Gut metabolites acting on the gut-brain axis: regulating the functional state of microglia
It is a tripeptide composed of cysteine, glycine, and glutamine, three amino acids that form a crucial component of the bodys key antioxidant defense system
In Vitro: Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 M. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met
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