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At the same time, the visible nature of weight loss can reinforce adherence, at least in the early stages

Peer review Peer review information Nature Metabolism thanks Nigel Irwin, Michael Nauck and Brian Finan for their contribution to the peer review of this work

None of the other pooled adverse pregnancy outcomes reached statistical significance, although several estimates remained imprecise

The disadvantage is the metabolic disruption of stopping and starting, which may reduce the efficiency of subsequent treatment courses

It's important to note that weight loss itself is an evidence-based therapy for GERD, so the weight reduction achieved with these medications may actually improve reflux symptoms in some patients, potentially offsetting any direct effects on the gastroesophageal junction