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All enzymatic systems show more enhanced activity in the population without Down syndrome than in the children with Down syndrome, however, there was no statistically significant difference between the two groups

CJC-1295 (GHRH analog) produces sustained GH and IGF-1 elevations [2]

In vitro studies have demonstrated that GHK-Cu increases the production of metalloproteinases and their inhibitors (TIMPs), enabling coordinated matrix remodeling rather than simply increasing matrix deposition

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Both compounds have attracted clinical interest due to their roles in energy metabolism, cardiovascular health, and potential therapeutic applications in various conditions characterised by mitochondrial dysfunction or energy deficiency