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GLP-1 signaling pathway Dysregulation of the GLP-1/GLP-1R signaling cascade, such as diminished ligand secretion, receptor desensitization, or biased signaling, disrupts systemic homeostasis and contributes to pathological states including insulin resistance (IR), -cell dysfunction, endothelial impairment, chronic inflammation, and neurodegeneration

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In this paper, the latest evidence on the relationship between LA and MASLD is reviewed to provide valuable insights for future explorations into mechanisms and to aid clinical investigations