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In the phase-2 trials, as many as 6080% of participants experienced stomach problems, such as nausea, vomiting, diarrhea or constipation, at the higher doses

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In the wider literature, established evidence from randomised controlled trials, albeit in non-CKD populations, generally support GLP-1 RAs (notably once-daily semaglutide over 52 weeks) for HbA1c and weight benefits, owing to the strength of evidence demonstrating their role in body weight, glycaemic and blood pressure reduction [25, 27]