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When comparing metformin and semaglutide, the evidence points in a clear direction for most people who want meaningful weight loss

While GLP-1R agonists have demonstrated cardiovascular benefits in clinical trials, including reduced rates of major adverse cardiovascular events (MACE) in T2DM patients, their antithrombotic efficacy is generally considered less potent than that of traditional antithrombotic agents

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& Brosnan, J

This may be an additional source of selection bias since some genital abnormalities such as varicocele may impact the outcome of AOX therapy of infertile men [36, 92]