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Most reports were in patients with at least one predisposing risk factor (e.g., diabetes)

Archived from the original on 2017-08-14

Peripheral arterial disease , more prevalent in people with diabetes, can cause exertional calf pain (claudication), cold feet, absent pulses, and delayed healing

The peptide suppresses formation of pro-inflammatory mediators including TGF-1, creating an environment conducive to regeneration rather than chronic inflammation