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What the Pivotal Trial Actually Measured STEP 1 enrolled 1,961 adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related coexisting condition, none of whom had diabetes

GLP-1 receptor agonists may help reduce binge eating episodes by modulating appetite signals in the brain, though clinical evidence for this indication remains limited compared to weight loss applications

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It competitively inhibits pathogen adhesion to IECs, produces antimicrobial metabolites (e.g., lactic, acetic, and propionic acids, bacteriocins, ROS), and strengthens host defenses (234)

At the end of the day, the best dosing strategy is the one thats appropriate for your body, your history, and your goals