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Faizah Shareef is an Internal Medicine Resident Physician and a member of the ABC News Medical Unit.

Furthermore, the severity and incidence of HACE may be influenced by physiological processes related to ubiquitination and polymorphisms of key enzymes [7]

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Freezing can permanently damage the peptide structure

As a typical damage-associated molecular pattern (DAMP) molecule, HMGB1 can mediate heat stress-induced NLRP3 inflammasome activation via the TLR4 and receptor for advanced glycation end products (RAGE) signaling pathways, thereby promoting IL-1 activation and inducing hepatocyte pyroptosis, ultimately leading to severe liver injury in rats [26]