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Considering the above and given that hepatic fibrosis is the main histological prognostic factor for advanced NAFLD and a target that is difficult to reverse [51], it may be speculated that GLP-1RAs could possibly be provided in earlier stages of the disease before the occurrence of hepatic fibrosis

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The declining levels of IGF-1 in GF mice are associated with retarded linear growth, reduced body weight, and impaired bone formationincluding shorter femur length, lower cortical bone density, and reduced trabecular bone densityall of which indicate that GM plays an important role in optimizing growth