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Description

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We hope to generate a better version of MOTs-C and bring it back into clinical development, Cohen says

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In physiological conditions, GPR17 is required to initiate OPC differentiation, but must be downregulated to allow cells to undergo terminal maturation

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In summary, skin barrier disruption functions as a pathophysiological hub that integrates and coordinates fibrosis gene signals (TGF-/Smad), immune bias (Th2/STAT6), and upstream mechanical signals (YAP/TAZ), rather than being just a simple clinical symptom (Bieber 2022

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Xicoy H, Wieringa B, Martens GJM

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