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Zhao et al., 2016), as discussed in more detail in Section 4 E3 ligases and deubiquitinating enzymes in circadian regulation. 2.3 Turnover of core clock proteins The timed degradation of core clock proteins by the ubiquitin-proteasome system ensures proper cycling between repression and activation within the feedback loop, maintaining clock period length

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The retina is a tissue with high oxygen consumption and, when it is in a high glucose state, antioxidants such as reduced GSH are consumed in large quantities, making it more vulnerable to damage than other organs (59)

However, it is the leading cause of acute liver failure in the United States [1, 2], with unintentional poisoning slightly surpassing intentional overdose cases