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Summers, Ilga Mutule, Edgars Suna, Jesper V

A list of software used is available in the Methods section and Reporting Summary

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Adverse Effects and Black Box Warnings Side effects most commonly seen in patients taking Meglitinides include (14): Weight gain Whipple triad Hypoglycemia Symptoms of hypoglycemia Shakiness Increased hunger Sweating Fatigue Irritability Anxiety Lightheadedness Heart palpitations Confusion More severe Changes in vision or speech Seizures Loss of consciousness Coma Hypoglycemia 30mL/min/1.73

-3 DPA Protected neurons from neuroinflammation by balancing microglia M1/M2 polarizations through inhibiting NF-B/MAPK p38 signaling and activating neuron-BDNF-PI3K/AKT Pathways