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doi: 10.3390/ijms22126531 254 van de VeerdonkFLRengaGParianoMBelletMMServilloGFallarinoFet al

Our model provides a comprehensive assessment of disease progression through multiple validated endpoints: Clinical score Body temperature Body weight evolution Viral load (nasal washes, BAL, lungs and nasal turbinates) Histopathology The model consistently reproduces the key hallmarks of influenza infection, including clinical signs, transient fever, body weight loss, significant viral replication in respiratory tissues and characteristic inflammatory lesions

The meta-analysis included 21 trials (10 PIONEER and 11 SUSTAIN trials) involving 12,260 semaglutide users

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