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For cagrilintide , the most significant trial programme involves its combination with semaglutide (CagriSema), investigated in the REDEFINE trial series

Collectively, these data suggest that expression levels of the uptake and extrusion transporters are not necessarily the limiting factors determining the anti-proliferative effects of metformin and that genetically determined variations in signaling pathways are variably important as are nutrient levels in the tumor microenvironment (249, 254)

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