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PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility

Limited effectiveness : Natural ingredients cannot replicate the transformative effects of GLP-1 injections

Es importante destacar que la interrupcin del tratamiento suele ser la causa de una rpida recuperacin del peso, lo que compromete los beneficios obtenidos a largo plazo

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[10] In these situations an oral supplement may be inadequate or too slow, so clinicians rely on intravenous or intramuscular levocarnitine