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Besides passive diffusion across bilayer membranes, uptake or efflux via membrane transporter molecules is of high significance for compound absorption, distribution and elimination ( metabolite was observed to be subjected to facilitated uptake via GLUT-1 transporters into erythrocytes and endothelial cells ( For Pycnogenol constituents and metabolites, interactions with some specific structures, such as matrix proteins ( in vitro

doi: 10.1111/j.1464-410X.2005.05590.x

Your body can only use so many vitamins, and if you're not deficient, you're essentially creating expensive urine (as one doctor colorfully put it)

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