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In clinical trials, patients at the therapeutic dose lost an average of approximately 15 to 17 percent of body weight over 68 weeks

Lauren Dowell is no longer affiliated with Baylor College of Medicine or Texas Childrens Hospital

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Tryptophans regulation of ferroptosis involves mechanisms such as the kynurenine pathway (KP) ( Figure 2 ), where host cells generate multiple tryptophan metabolites, including L-kynurenine (L-KYN), kynurenine (KYN), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HA), and KYN