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Among metabolic detoxification enzymes, GST is a family of multifunctional enzymes that are ubiquitously present in eukaryotes and prokaryotes, playing an important role in the detoxification of numerous endogenous and exogenous compounds

2019;8:e45572

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By integrating mechanistic and translational insights, this review provides a novel foundation for precision intervention strategies targeting SIRT1 network reprogramming