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This level of efficacy approaches that of bariatric surgery, signaling a potential paradigm shift in non-invasive weight management

481 Neurodegeneration and abnormal nervous tissue development is, arguably, triggered by the invasion of amniotic fluid into the developing spinal cord and adding to the mechanical trauma

Sources: OASIS 4 (Wharton et al, NEJM 2025), SURMOUNT-1 (Jastreboff et al, NEJM 2022), COR programme trials, NICE TA875/TA664

When used as part of a comprehensive program, including lifestyle changes, patients have reported significant weight loss

Highlights Retatrutide is a novel triple hormone receptor agonist that simultaneously targets GLP-1, GIP, and glucagon receptors to regulate appetite and energy expenditure