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The SELECT cardiovascular outcomes trial showed that semaglutide 2.4 mg significantly reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) in patients with established cardiovascular disease and overweight or obesity, even without type 2 diabetes
Both medication classes can influence cardiovascular parameters and glucose metabolism in ways that may require monitoring and dose adjustments
N Engl J Med 355:22972307 Aithal GP, Thomas JA, Kaye PV et al (2008) Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
[39] Ultimately, it leads to easier to pass, softer stool , [40-42] yet helps reduce diarrhea as opposed to causing it