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5 Reactive oxygen species as oxidizing agents: impact on cysteine proteinases and cellular homeostasis It has long been established that disturbances in reactive oxygen species (ROS) regulation generate highly reactive cellular environments, profoundly influencing intracellular signaling pathways and contributing to oxidative stress

5.3 Therapeutic strategies to enhance antioxidant defense Given the limitations of sperms natural antioxidant defenses, therapeutic strategies aimed at enhancing antioxidant capacity are essential for protecting sperm from oxidative stress and improving male fertility (103)

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Collectively, these findings raise the possibility that the mechanism of glucocorticoids increasing serum IGF-I levels is by directly inducing post-IGF-IR signaling resistance