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For orforglipron, participants initiated on higher doses and those on rapid titration schemes appeared to have higher discontinuation rates, providing insights into the optimisation process for the phase 3 trials

Tirzepatide has six weekly doses, while semaglutide has five

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After intravital tetracycline labelling on days 0, 6, and 13, LGR was determined bymeasuring the distance between the respective fluorescent bands in the proximal tibia metaphysis