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Vit E phenolic hydroxyl groups interrupt lipid peroxidation chains, increasing GPx/SOD [548] and blocking TGF-1- Phosphorylated extracellular signal-regulated kinase(pERK), phosphorylated extracellular signal-regulated kinase (pSmad2), and phosphorylated c-Jun N-terminal kinase (pJNK) fibrosis signaling [549], while increasing Roseburia abundance [550]

Therefore, the interaction between mitochondrial -oxidation and ER stress in the process of regulated lipid metabolism by dietary LC should be studied in the future, which will assist in increasing our understanding of the regulatory mechanism used by dietary LC on lipid metabolism