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The results demonstrated that early and middle-stage treatment with hydrogen-saturated saline significantly improved cardiovascular and motor dysfunction, reduced neuronal loss, ROS, and -syn accumulation, and activated autophagy by inhibiting the PI3K/AKT/mTOR pathway
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Treatment with 4-hydroxytamoxifen (4-OHT) activates ER:RAS, inducing senescence (Supplementary Fig
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