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NF-B plays a critical role in the initiation and perpetuation of inflammation

While clinical data is limited, peptide therapy may have a place in hormone regulation

To address the need for strategies to introduce chemical complexity and conformational control into peptide macrocycles, we report here that linear peptides with a reactive N-terminal -keto or -keto amide can be synthesized ribosomally

Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response