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While some researchers suggest that Trp cage explains the superior binding affinity of Ex4 relative to GLP-1, studies have shown that specific divergent residues in the C-terminal part of Ex4 contribute to greater interactions with the receptor (Runge et al

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Gnecchi-Ruscone GA, Abondio P, De Fanti S, Sarno S, Sherpa MG, Sherpa PT, Marinelli G, Natali L, Di Marcello M, Peluzzi D, Luiselli D