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A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group

Steady-state plasma concentrations are typically achieved after approximately four to five weeks of weekly dosing

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While alopecia appears in Wegovy's FDA label at low frequency, hair loss during semaglutide treatment more commonly results from rapid weight loss triggering telogen effluvium rather than direct drug effects

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