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Prior work has established that Alistipes increases from diets rich in protein and fat, and contributes to the highest number of putrefaction pathways (i.e., fermentation of undigested proteins in the GI tract) over the other commensals 59
100 The mechanisms underlying this inhibition of secretion have not been extensively studied, and its effects on blood glucose regulation remain unclear
In terms of mitochondrial function, GLP-1RAs act through multiple pathways: first, stimulating mitochondrial biogenesis via the AMPK signaling pathway to boost both the number and functionality of mitochondria (93)
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