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A number of positive anti-inflammatory actions of thiamine include activation of Nrf2 and decreased ROS levels, enhanced activity of mitochondrial respiratory chain complexes I-IV, downregulation of endoplasmic reticulum stress, and suppression of gene expression associated with mitophagy, oxidative stress, and proinflammatory cytokines (205)

and E.H.), the Swedish Medical Research Council (E.H.), the Birgit Backmark Foundation (E.H.), the Swedish Brain Foundation (E.H.), the Sderberg Foundation (E.H.), and the Association Amici del Centro Dino Ferrari (S.C.)

These effects are typically related to its interaction with the ghrelin receptor and secondary hormonal systems

doi:10.1016/j.immuni.2015.10.012

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