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The effect of combination therapy on body weight might be explained by the effects on brain centers that control energy balance, contributing to increased appetite in response to SGLT-2i and decreased food intake with GLP-1RA [45]

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FDA-Approved Medications GLP-1 therapies including Semaglutide and Tirzepatide clinically proven to reduce appetite and support significant, sustained weight loss

They may skip meals, avoid protein because they feel too full, or rely on very small portions that do not support muscle maintenance