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Previous studies showed that HIP can be successfully exploited for EXEN loading into SEDDS, which resulted in oral bioavailability of approximately 28 % (Ismail et al., 2020)

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A subsequent head-to-head trial, SURMOUNT-5, found that Tirzepatide outperformed Semaglutide with an average weight reduction of 20.2 percent compared to 13.7 percent over the same period, marking the first direct clinical comparison between the two leading GLP-1 medications