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At tissue level, RAS (renin-angiotensin system) can be upregulated with non-hemodynamic effects ( Several studies reported that inappropriate ANGII/AT1R activation occurs because of different mechanisms, particularly in patients with T2DM

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Acetyl-l-carnitine (ALC), a natural substance marketed over the counter as a dietary supplement, is popular among cancer patients as a result of preclinical and early-phase data in chemotherapy-related neuropathy and also a study in patients with diabetes-related peripheral neuropathy