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In some cases, they can be life threatening

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On one hand, IL-1, IL-18, and other damage-associated molecular patterns released by pyroptosis recruit and activate additional immune cells (77, 78), further exacerbating oxidative stress and weakening the antioxidant defenses of adjacent periodontal cells, rendering them more susceptible to ferroptosis (79)

Induction of reactive oxygen species by HTLV-1 tax correlates with DNA damage and expression of cellular senescence marker

Additionally, the high cost of these medications remains a major barrier, requiring policy changes to ensure broader insurance coverage and affordability