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Indeed, a recent clinical study demonstrated that giving oral propionate (a microbial metabolite) to MS patients increased their peripheral Treg counts and was associated with a lower annual relapse rate over the ensuing 3 years [188]

The logic here is that the underlying pathology is not resolving as cleanly as an acute mechanical injury, and ongoing mucosal protection may require sustained peptide signaling

Even though current evidence suggests GLP-1 medications do not show an increased risk of suicidal thoughts or behaviors when used as prescribed, individuals should report any mood changes to their healthcare provider

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Patients with significant acne concerns should pursue concurrent evidence-based dermatologic care, which may include topical retinoids, benzoyl peroxide, topical or oral antibiotics, hormonal therapies, or isotretinoin depending on acne severity and type