semaglutide fatigue reddit Saw this on bsky and thought it'd be relevant : r/cfs GLP-1s for Weight Loss: Obesity

the oral option Foundayo is already FDA-approved and available for patients who want to avoid injections entirely Who Faces the Greatest Benefit From Extended-Dosing Options Based on current research on GLP-1 adherence challenges: Patients with needle phobia or injection anxiety who have delayed starting GLP-1 therapy Patients who report forgetting their weekly injection or injecting on the wrong day People with irregular weekly schedules including shift workers, frequent travelers, and caregivers for whom a consistent weekly schedule is difficult to maintain Patients who stopped weekly GLP-1 therapy specifically because of the injection burden An oral pill eliminates injection entirely and is already available through Foundayo for eligible patients

After cryoprotection with 30% sucrose in 0.1 M PBS brains were sectioned coronally at 30 m thickness

No clear and welldefined circuitlevel mechanism has been identified yet, instead GLP1 seems to modulate brain circuits at multiple levels, and the relevant mechanisms of action may well be species dependent

Its levels decline with age, which correlates with reduced skin repair, slower hair growth, and increased signs of aging

Nutr., 39 : 503-513)