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These include immune-mediated cytokine release, hormonal modulation through the hypothalamicpituitaryadrenal (HPA) axis, and neural pathways involving both the enteric nervous system (ENS) and the vagus nerve (Guzzetta et al., 2022

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The protocol would ideally focus on populations likely to benefit most from senolytic therapy, such as the elderly or patients with diseases characterized by a high burden of senescent cells