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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

This GLP-1 receptor agonist works primarily on the pancreas, brain, and gastrointestinal tract rather than the biliary system directly

This is not an action for individuals to undertake on their own

A 2024 FDA safety review identified reports of suicidal thoughts in some users, though causality remains unclear

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