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Approximately 20% of patients with primary ovarian insufficiency (POI) have been diagnosed with other autoimmune diseases, often thyroid, adrenal, and pancreatic diseases, and approximately 10% of patients with Addisons disease develop POI ( Figure 2 2.1.3 Iatrogenic factors Chemotherapy has multiple effects on ovarian function ( 2.1.4 Metabolic factors Ovarian function is decreased in patients with galactosemia, but the mechanisms responsible for this remain unclear

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Here is a graphical representation of what is going on in a mitochondrion in depression

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