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High-grade sepsis was used in our experiments as described (40), which resulted in survival rates of ~25%

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In fact, a few previous studies have shown that AM404 decreases neuronal c-fos -positive immunoreactivity induced by non-noxious stimulation of the spinal cord in a rat model of neuropathic or inflammatory pain, and these responses are inhibited by TRPV1 or CB1 receptor antagonists (Rodella et al., 2005

IRS recruitment activates phosphoinositide 3-kinase (PI3K), which phosphorylates PIP2 to PIP3, recruiting Akt/PKB to the membrane for activation by PDK1 this PI3K/Akt arm drives protein synthesis via mTORC1, glucose uptake via GLUT4 translocation, and cell survival via BAD phosphorylation